Hiles, S. A., Harvey, E. S., McDonald, V. M., et al. (2018) Working while unwell: Workplace impairment in people with severe asthma. Clinical & Experimental Allergy, in press.

Working while unwell – known as presenteeism – was much more common in people with severe asthma (73%) than non-severe asthma (44%). Presenteeism was associated not just with poor control of asthma symptoms, but also with symptoms of depression and anxiety.

Wassink-Vosse, S., Collard, R. M., Penninx, B. W. J. H., Hiles, S. A., Oude Voshaar, R. C., Naarding, P. (2018) The reciprocal relationship between physical activity and depression: Does age matter? European Psychiatry, 51, 9-15.

Clark, V. L. , Gibson, P. G., Genn, G., Hiles, S. A., Pavord, I. D. & McDonald, V. M. (2017). Multidimensional assessment of severe asthma: A systematic review and meta‐analysis. Respirology, 22 (7), 1262-1275.

Hiles, S. A., Lamers, F., Milaneschi, Y., & Penninx, B. W. J. H. (2017). Sit, step, sweat: Longitudinal associations between physical activity patterns, anxiety and depression. Psychological Medicine, 1-12.    Download article.

This study showed that participating in physical activity, particularly organised sport, was associated with reduced depression and anxiety into the future. The reverse was also true – depression and anxiety were associated with lower sports participation into the future. This is probably because similar factors underlie good mental health and participating in sports – things like motivation, organisation, social connectedness and certain biological factors. 

Hiles, S. A., Révész, D., Lamers, F., Giltay, E. & Penninx, B. W. J. H. (2016). Bi-directional prospective associations of metabolic syndrome components with depression, anxiety and antidepressant use. Depression and Anxiety, 33, 754-764.    Download article. 

The focus of this study was the link between mental and metabolic health. We saw that worse symptoms of depression or anxiety and using antidepressants were related to poorer metabolic health (especially obesity) and short-term worsening of metabolic health. This research highlights that it is important to monitor metabolic health in people with depression and anxiety.

Hu, M. X., Lamers, F., Hiles, S. A., Penninx, B. W., & de Geus, E. J. (2016). Basal autonomic activity, stress reactivity, and increases in metabolic syndrome components over time. Psychoneuroendocrinology, 71, 119-126.

The autonomic nervous system is one of the key systems involved in our stress response. This study shows that this stress system is also associated with metabolic health.

Lai, J. S., Oldmeadow, C., Hure, A. J., McEvoy, M., Hiles, S. A., Boyle, M., & Attia, J. (2016). Inflammation mediates the association between fatty acid intake and depression in older men and women. Nutrition Research, 36 (3), 234–245.

Hiles, S. A., Baker, A. L., de Malmanche, T., McEvoy, M., Boyle, M. & Attia. J. (2015). Unhealthy lifestyle may increase later depression via inflammation in older women but not men. Journal of Psychiatric Research, 63, 65-74.

Hiles, S. A., Baker, A. L., de Malmanche, T., McEvoy, M., Boyle, M. & Attia. J. (2015). The role of inflammatory markers in explaining the association between depression and cardiovascular hospitalisations. Journal of Behavioral Medicine, 38 (4), 603-619.

An increasingly well-known theory suggests one cause of depression might be a faulty immune system. We wanted to test if this theory could explain why people with depression get cardiovascular disease more often than their peers. Our answer was “maybe”…. it may be one reason, but there are also other reasons people with depression get cardiovascular disease.

Hiles, S. A., Bergen, H., Hawton, K., Lewin, T., Whyte, I. M., Carter, G. (2015). General hospital-treated self-poisoning in England and Australia: comparison of presentation rates, clinical characteristics and aftercare based on sentinel unit data. Journal of Psychosomatic Research, 78 (4), 356-362.

Handley, T., Hiles, S. A., Inder, K., Kay-Lambkin, F., Kelly, B., Lewin, T., McEvoy, M., Peel, R. & Attia, J. (2014). Predictors of suicidal ideation in older people. A decision-tree analysis. American Journal of Geriatric Psychiatry, 22 (11), 1325-1335.

Lai, J. S., Hiles, S. A., Bisquera, A., Hure, A. J., McEvoy, M. & Attia, J. (2014). A systematic review and meta-analysis of dietary patterns and depression in community- dwelling adults. American Journal of Clinical Nutrition, 99 (1), 181-197.

Hiles, S. A., Baker, A. L., de Malmanche, T. & Attia, J. (2012). A meta-analysis of differences in IL-6 and IL-10 between people with and without depression: Exploring the causes of heterogeneity. Brain, Behavior, and Immunity, 26 (7), 1180-1188.

Baker, A. L., Hiles, S. A., Thornton, L., Hides, L. & Lubman, D. I. (2012). Psychological interventions for excessive alcohol consumption among people with psychotic disorders: A systematic review. Acta Psychiatrica Scandinavica, 126 (4), 243-255.

Hiles, S. A., Baker, A. L., de Malmanche, T. & Attia, J. (2012). Interleukin-6, C-reactive protein and interleukin-10 after antidepressant treatment in people with depression: A meta-analysis. Psychological Medicine, 42(10), 2015-2026.

Baker, A. L., Thornton, L., Hiles, S. A., Hides, L. & Lubman, D. I. (2012). Psychological interventions for alcohol misuse among people with co-occurring depression or anxiety disorders: A systematic review. Journal of Affective Disorders, 139 (3), 217-229.

Walker, A. K., Hiles, S. A., Sominsky, L., McLaughlin, E. A. & Hodgson, D. M. (2011). Neonatal lipopolysaccharide exposure impairs sexual development and reproductive success in the Wistar rat. Brain, Behavior and Immunity, 25(4), 674-684.